Immune modulatory effects of food supplement products Zeng Jian Heath Tonic and Zhen Yuan Capsule in elderly mice

Immunosenescence is the degeneration of immunological organs and cells due to aging. Some plants fungi may have anti-aging benefits through regulating immunosenescence. In this study, mice were fed with two dietary supplement products: Zeng Jian Health Tonic (ZJ) contains extracts from Lentinula edodes, Poria cocos, Tremella fuciformis, cassia seed, Flammulina velutipes, Fructus lycii, chrysanthemum, mulberry. Zhen Yuan Capsule (ZY) Ganoderma lucidum, Semen cuscutae, Schisandra chinensis, Codonopsis pilosula, Atractylodes macrocephala. addition, immune organ index, cell functions, inflammatory cytokines, antioxidant enzyme activities evaluated. The combination ZJ ZY could restore function lymphocytes NK cells; decrease level pro-inflammatory cytokines including IL-1α, IL-1β, GM-CSF; increase anti-inflammatory cytokine IL-5; enhance superoxide dismutase glutathione peroxidase activities. Therefore, combining has effects on elderly mice.